TABLE 3.

LncRNAs in secondary changes of myocardial infarction.

LncRNA	Target	Function	References
lncCIRBIL	Bclaf1	Reduced infarcted area after I/R and cardiac protection.	Zhang Y. et al., 2021
HOTAIR	EZH2/miR-451/CAB39	Regulates oxidative stress and cardiac myocardial apoptosis during I/R	Meng et al., 2020
H19	COL1A1	Form H19-YB-1 complex to decrease COL1A1 expression and preventing ECM deposition and cardiac remodeling after MI.	Choong et al., 2019
SAIL	SAFB	Regulating cardiac fibrosis by promoting SAFB bind to rpb1.	Luo et al., 2021
Safe	Sfrp2 mRNA	Binding Sfrp2 mRNA 3′-UTR and inhibited TGF-β- induced fibrosis.	Hao et al., 2019
Cfast	COTL1/TRAP1/TGF-β signaling pathway	Competitively inhibits the interaction between COTL1 and TRAP1, thereby enhancing fibrosis-related gene expression and myofibroblasts transdifferentiating into CFs.	Zhang F. et al., 2021
lncRNA 554	TGF-β1 signaling pathway	Regulate CFs migration and ECM expression following MI.	Luo et al., 2020
Chast	Plekhm1	Prevent cardiac remodeling and hypertrophy.	Viereck et al., 2016
Wisper	TIAR	Reduce the development of myocardial fibrosis after MI and prevent adverse remodeling.	Micheletti et al., 2017