Table 1.
Baseline characteristics of hospitalized COVID-19 patients with and without respiratory bacterial co-infection.
| N = 228 | Respiratory bacterial co-infection (n = 57) | No respiratory bacterial co-infection (n = 171) | P-Value |
|---|---|---|---|
| Age, years | 68 [60-76] | 58 [43-71] | 0.0003 |
| Male | 36 (63%) | 92 (54%) | 0.22 |
| Admission from SNF/LTAC/NH | 27 (47%) | 26 (15%) | <0.0001 |
| Charlson Comorbidity Index | 3 [1-4] | 2 [0-4] | 0.08 |
| COPD | 14 (25%) | 14 (8%) | 0.001 |
| Asthma | 7 (12%) | 17 (10%) | 0.62 |
| Interstitial Lung Disease | 5 (9%) | 0 (0%) | <0.0001 |
| Cardiac Disease | 15 (26%) | 31 (18%) | 0.18 |
| Diabetes Mellitus | 24 (42%) | 67 (39%) | 0.7 |
| Immunocompromised | 7 (12%) | 33 (19%) | 0.23 |
| COVID-19 Severity | |||
| Mild to Moderate | 4 (7%) | 73 (43%) | <0.0001 |
| Severe | 53 (93%) | 98 (57%) | |
| Procalcitonin (n = 116) | 0.31 [0.16-0.95] | 0.15 [0.07-0.67] | 0.01 |
| WBC | 11.7 [7.2-15.6] | 8.0 [5.7-11.5] | 0.0001 |
| CRP (n = 190) | 139.7 [85.4-249.2] | 105.6 [30.7-161.3] | 0.003 |
| Ferritin (n = 186) | 927.2 [513.5-2,264.3] | 666.7 [251.1-1,231.3] | 0.02 |
| IL-6 (n = 81) | 99.4 [26.6-302.5] | 44.2 [20.5-107] | 0.1 |
| Temperature (F) | 100.6 [99.3-102.3] | 100.1 [98.9-101.4] | 0.04 |
| Glucocorticoids | 34 (60%) | 62 (36%) | 0.002 |
| Tocilizumab | 5 (9%) | 8 (5%) | 0.25 |
SNF = skilled nursing facility; NH = Nursing Home; LTAC = long term acute care; WBC = white blood cell; IL-6 = interleukin-6; COPD = chronic obstructive pulmonary disease; CRP = C-reactive protein.
Maximum WBC, ferritin, IL-6, CRP were collected within 72 hours of admission. Temperature was collected within 24 hours of admission.
Data are presented as median [IQR] or number (%) as appropriate.