Table 1.
Summary of candidate circRNAs as biomarkers in kidney diseases.
| CircRNA | Disease | Specimen | Expression change | Significance as biomarker | References |
|---|---|---|---|---|---|
| circEGLN3 | RCC | Kidney tissues | Up | As diagnostic biomarker of RCC; up-regulation predicts better prognosis | (49) |
| circRHOBTB3 | RCC | Kidney tissues | Down | As diagnostic biomarker of RCC; down-regulation predicts poor prognosis | (49) |
| hsa_circ_0001451 | RCC | Kidney tissues | Down | As diagnostic biomarker of RCC; down-regulation predicts poor prognosis | (50) |
| circPCNXL2 | RCC | Kidney tissues | Up | Up-regulation predicts poor prognosis | (51) |
| circ-ABCB10 | RCC | Kidney tissues | Up | Up-regulation predicts poor prognosis | (52) |
| hsa_circ_001895 | RCC | Kidney tissues | Up | Up-regulation predicts poor prognosis | (53) |
| circ_001842 | RCC | Kidney tissues | Up | Up-regulation predicts poor prognosis | (54) |
| circPRRC2A | RCC | Kidney tissues | Up | Up-regulation predicts poor prognosis | (55) |
| circ-EGLN3 | RCC | Kidney tissues | Up | Up-regulation predicts poor prognosis | (56) |
| circ_0001368 | RCC | Kidney tissues | Down | Down-regulation predicts poor prognosis | (57) |
| cRAPGEF5 | RCC | Kidney tissues | Down | Down-regulation predicts poor prognosis | (58) |
| ciRs-126 | AKI | Blood | Up | Up-regulation predicts poor 28-day survival | (59) |
| hsa_circ_0001334 | acute kidney rejection | Urine | Up | As diagnostic biomarker of acute rejection; up-regulation predicts poor 1-year graft function | (45) |
| circ_101319 | IMN | Blood | Up | As diagnostic biomarker of IMN | (60) |
| circ_002453 | LN | Blood | Up | As diagnostic biomarker of LN | (61) |
| hsa_circ_0123190 | LN | Blood | Down | As diagnostic biomarker of LN | (62) |
RCC, renal cell carcinoma; AKI, acute kidney injury; IMN, idiopathic membranous nephropathy; LN, lupus nephritis.