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Potential clinical therapeutics targeting SIRPs and CD47 for type 1 diabetes prevention or suspension. Immunotherapies could be utilized to increase the expression of SIRPγ and/or CD47 on primary T cells for adoptive cell therapies or CD47 on stem cell-derived β-cells or islets before transplant to attenuate the magnitude of recurrent autoimmunity. Red Text Box: Expected Decrease; Green Text Box: Expected Increase.
