Table 1.
Analyzation of clinical treatments and results (patient less than six)
| Author (Year) |
Type of alopecia | Patient (Sex/Age) |
Intervention (Sort/ Site) | Outcome measurement | Result | Adverse events |
|---|---|---|---|---|---|---|
| Yun (2001) [21] |
AA | 1 (M/37) |
1. HM: Hyeongbangjiwhang-tang + Rehmanniae Radix 2. Atx: Kidney tonification (腎正格) 3. Phx: (1) CF:JsD=7:3/ Alopecia region (2) HH/ GB21 (3) CC/ BL23 4. Cupping therapy: Dry cupping/ Shoulder region 5. Phototherapy: IR/ Head area 6. Blood-letting therapy: Alopecia region |
1. Subjective symptoms change | 1. Hair loss (6 points) → Improved (4 points), Slightly improved (2 points) | N.R |
| Kim (2004) [22] |
AA | 1 (M/30) |
1. Atx: GV20, GB20, A-shi point 2. Phx: (1) BV (10000:1)→(4000:1)→(2000:1)/ Center&border of scalp (2) CF/ Center&border of scalp |
1. Visual evaluation&Pictures 2. EEAA |
1. Improved 2. 0 → 3 |
Slightly pruritus (BV) |
| Ha (2004) [15] |
AT | 1 (M/8) |
1. HM: Yangdokbeakho-tang Gamibang → Samul-tang + Yukmijihwang-tang → Samulgamri-hwan 2. Atx: Kidney tonification(腎正格), Friction acupuncture/ Scalp |
1. Visual evaluation&Pictures | 1. Improved | N.R |
| Lee (2008) [16] |
AU | 1 (M/38) |
1. Phx: BV/ Alopecia starting point, Parietal Region feeling stiff tension 2. Life management: lightly shampooing once a day, wiping hair with a towel and drying it after shampoo |
1. Visual evaluation&Pictures 2. VAS (Alopecia, Tension of scalp) 3. SALT score 4. Stress index |
1. Improved 2. (1) Alopecia: 7 → 3 (2) Tension: 5 → 1 3. S2 (39.8% → 43.0%) 4. 37 → 38 |
Dazed (1 h) |
| Lee (2009) [23] |
AA | 1 (F/19) |
1. HM: not mentioned 2. Phx: CF/ Alopecia region 3. Atx: GV20, ST8, GV23, GV21, BL6, EX-HN1, GB20 4. Life management: only shampooing once a day, reduce eating processed food |
1. Visual evaluation&Pictures 2. VAS (Patient's awareness about hair loss progress) 3. Stress index 4. EEAA 5. Response of treatment |
1. Improved 2. 9 → 2 3. 48 → 43 4. 0 → 3 5. No → Good |
N.R |
| Hwang (2012) [24] |
AA | 1 (F/5) |
1. HM: Shihogayonggolmoryeo-tang → Baekhogainsam-tang | 1. Visual evaluation&Pictures | 1. Hair loss patch diameter (cm): 2.5 → 0.5 | N.R |
| Ju (2013) [18] |
AA | 1 (F/13) |
1. HM: Galgeun-tang → Banhabackchulchunma-tang → Galgeun-tang → Soshiho-tang + Rhinocerotis Cornu→ Soshiho-tang + Rhinocerotis Cornu, Daehamhyung-hwan 2. Atx: A-shi point (Hair loss area), CV4 3. Phx: (1) HP/ 2 cm outward of lesion to inward (2) JsD/ Induratum of upper trapezius, GB21, Intersecting points (Medial line of scapula&T3·T7 height), LU1 (3) BUM/ BL32, BL34, Inner point of 12 ribs end, Inner point of ASIS 4. External medicine or product : Scalp mist, Shampoo 5. Phototherapy : (1) High frequency wave therapy/ Trapezius (2) Low frequency wave therapy/ Shoulder, Back (3) IR 6. Cupping therapy : Dry cupping/ Shoulder region 7. Microneedling : GL/ Alopecia region 8. Galvanic |
1. Visual evaluation&Pictures | 1. Improved | -Drowsiness after meals -Headache |
| Yoon (2014) [19] |
AGA | 1 (F/42) |
1. HM: Soshiho-tang 2. Atx: GV20, EX-HN1, ST8, LI4, KI3, BL2, TE23, GB1, ST1, A-shi point (Scalp, Circumbulbar) 3. Phx: HH/ Whole Parietal region 4. Needle embedding: Scalp |
1. Visual evaluation&Pictures 2. VAS (Cephalic fever and perspiration) 3. Ludwig classification |
1. Improved 2. 10 → 1 3. Grade 2 → 1 |
-Pain -Aching (1 d) |
| Ko (2016) [25] |
AGA | 1 (M/27) |
1. HM: Hyeongbangjihwang-tang Gamibang 2. Atx: CV12, ST36, LI4, EX-HN5, LR3 3. Phx: V/ Frontal region, CV1 + HA/ GB21, GB20, BL31 → V/ Frontal region + HA/ Frontal region |
1. Visual evaluation&Pictures 2. Subjective evaluation (Pruritus&Seborrhea) |
1. Improved 2. Improved |
Diarrhea (degeneration) |
| Kim (2016) [17] |
AA (by CA) |
1 (M/19) |
1. HM: Daeyeong-jeon 2. Atx: A-shi point (Alopecia region) 3. Phototherapy: Hani-maehwa Laser/ Alopecia region |
1. Visual evaluation&Pictures | 1. Improved | N.R |
| Kim (2016) (2) [26] |
AA | 1 (F/42) |
1. HM: Shipjeondaebo-tang Gamibang 2. Atx: A-shi point (Alopecia region), ST36, LI4 3. Ptx: HH/ Scalp 4. External medicine or product: Herbal spray (Houttuyniae Herba, Perillae Folium, Betulae Cortex)/ Scalp 5. Phototheraphy: IR 6. Needle-embedding: Scalp |
1. Visual evaluation&Pictures 2. VAS (subjective symptoms changed) |
1. Improved 2. 10 → 1 |
N.R |
| Yoon (2017) [27] |
AA | 4 (M/39, M/35, M/26, M/25)* |
1. HM: Gagam Cheongyoung-tang 2. Atx: GV20, GV22, BL7, PC6, KI3, LR2 3. External medicine or product: Scalp soothing ointment (Rehmanniae Radix, Osterici Radix, Liriopes Radix, Saposhnikovia Radix, Bupleuri Radix, Scutellariae Radix, Laminariae Thallus, Ecliptae Herba, menthol)/ Crown of the head (Arounding GV20) |
1. Visual evaluation&Pictures | 1. Improved | None |
| Choi (2017) [14] |
AA | 5 (M/46, M/30, M/27, F/53, F/22)† |
1. HM: Gagam Hwajung-hwan 2. Atx: GV20, EX-HN1, GB5 etc. (According to the symptoms) |
1. Visual evaluation&Pictures 2. Magnifying glass 3. SALT score |
1. Improved 2. Improved 3. (M/46): S1 → S0, (M/30): S2 →S0, (F/53): S2 → S0, (M/27): S2 →S0, (F/22): S1 → S0 |
N.R |
| Choi (2019) [28] |
AA | 1 (F/4) |
1. HM: Gagam Cheongyoung-tang→ Gagam Palmul-tang→ Gagam Cheongyoung-tang | 1. Visual evaluation&Pictures 2. Magnifying glass 2. SALT score |
1. Improved 2. Improved 3. S1 → S0 |
Diarrhea |
| Zhang (2019) [29] |
AA | 1 (M/36) |
1. Medicated thread moxibustion (Zhuang medicine): ST36, SP10, GV20, LR3, Kuihua acupoint | 1. Visual evaluation&Pictures 2. Pull test |
1. Improved 2. Improved |
N.R |
| Yun (2020) [30] |
AGA | 2 (M/70, M/60) |
1. HM: Yukmijihwang-hwan 2. External medicine or product: (1) Hair-growth tonic (Acori Calami Rhizoma, Glycyrrhizae Radix., Centellae herba, Sophorae Radix, Capsici Fructus, Camelliae Folium) (2) Hair-growth shampoo (Ligustici Rhizoma Acori Calami Rhizoma, Coicis Semen, Mori Radicis Cortex, Centellae herba, Camelliae Folium) |
1. Visual evaluation&Pictures 2. HNS |
1. Improved 2. No change |
N.R |
*Patients were already taking Finasteride over 1 year before treatment and during treatment accompanied Finasteride.
†Patients who were resulted S2 in SALT scale.
AA, Alopecia areata; AU, Alopecia universalis; AT, Alopecia totalis; AGA, Androgenetic alopecia; FA, Febrile alopecia; TE, Telogen effluvium; CA, Cicatricial alopecia; Atx, Acupuncture; HM, Herbal medicine; Phx, Pharmacopuncture; CF, Carthami Fructus; JsD, Juglandis Semen; HH, Hwangryunhaedoktang; CC, Cervi pantotrichum Cornu; BV, Bee Venom; EEAA, Evaluation of the effect on alopecia areata; VAS, Visual Analog Scale; SALT, Severity of alopecia tool; HP, Hominis placenta; BUM, Calculus bovis Fel ursi Moschus; GL, Ganoderma lucidum; HNS, Hamilton-Norwood scale.