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. 2021 Sep 16;11:742666. doi: 10.3389/fonc.2021.742666

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Copyright © 2021 Quaresmini, Di Lauro, Fucci, Strippoli, De Risi, Sciacovelli, Albano, Achille, Montepara, Russo, Tassone and Guida

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathology findings. (A, B) pre-treatment histology showing the presence of atypical neoplastic clones at high cellularity in the same sample: (A) field with melanocytic clone of cells rich in cytoplasmatic melanic pigment; (B) other field with an amelanotic clone displaying intense mitotic activity. (C, D) histologic sampling at complete response: (C) absence of neoplastic cells replaced by loose and dense fibrotic tissue with histiocytes; (D) histiocytes show cytoplasm intensely filled with melanic pigment.