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. 2021 Sep 16;12:751073. doi: 10.3389/fmicb.2021.751073

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Copyright © 2021 Zhan, Xu, He, Guan, Li, Li, Xie, Li, Chen, Cheng, Zhong and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagnostic performance and the real-world clinical impact of PneumoSeq. (A) Agreement between clinical diagnosis and testing results. Analyses were performed in 97 patients whose microbial etiology was diagnosed clinically, involving a total of 144 pathogens. PneumoSeq/Conventional Testing, pathogens identified by both methods in agreement with clinical diagnosis; Composite, pathogens identified by combining PneumoSeq and the conventional testing results; PneumoSeq Only and Conventional Testing Only, pathogens identified by an only single method. Left panel, by case; Right panel, by microorganism. (B) Evaluation of the clinical impact of PneumoSeq in ICO and ICH patients. Inner circle, ICO; Outer circle, ICH. The clinical impact was assessed as 1 of the 4 categories indicated with different colors.