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. 2021 Sep 16;12:723187. doi: 10.3389/fmicb.2021.723187

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Copyright © 2021 Wang, Xu, Xu, Yang, Wang and Zhan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphical summary of the effect of probiotic Bacillus subtilis DSM29784 (BS) exerts a protective effect against subclinical necrotic enteritis in broilers. BS reduces the risk of declined growth performance in chickens with SNE by enhancing exoenzyme secretion, intestinal barrier functions, and promoting the presence of beneficial commensal microorganisms and their metabolites in the intestine. SNE, subclinical enteritis; sIgA, secretory immunoglobulin A; CP, Clostridium perfringens; TJ, tight junction; AJ, adherens junction; DS, desmosomes. Ctr group, basal diet in control group; SNE group, basal diet+SNE (20-fold dose coccidiosis vaccine) +1ml of Clostridium perfringens (2×10⁸cfu/ml coinfection); BST group, basal diet (days 1–21)+1×10⁹ colony-forming units (cfu)/kg BS diet (days 22–63)+SNE.