Table 3.
Meta-analysis of subgroups.
| Type of subgroup | Eligible studies | OR (95% CI) | P value | Heterogeneity test | Effect model |
|---|---|---|---|---|---|
| Sex | |||||
| Male | 6 | 1.53 (1.20, 1.94) | =0.0006 | p < 0.00001, I2 = 85% | Random |
| Female | 6 | 1.90 (1.54, 2.33) | <0.00001 | P < 0.00001, I2 = 85% | Random |
| Both | 7 | 2.06 (1.31, 3.25) | =0.002 | P < 0.00001, I2 = 99% | Random |
| Age | |||||
| < 40 years old | 1 | 1.62 (1.39,1.89) | <0.00001 | Not applicable | Random |
| 40 ~ 50 years old | 8 | 2.14 (1.49, 3.08) | <0.0001 | P < 0.00001, I2 = 97% | Random |
| 50 ~ 60 years old | 2 | 1.50 (1.08, 2.07) | =0.01 | P < 0.00001, I2 = 95% | Random |
| 60 years old | 1 | 1.70 (1.36, 2.14) | <0.00001 | Not applicable | Random |
| Iodine nutrition status | |||||
| Iodine-deficient | 2 | 3.14(0.92, 10.73) | =0.07 | P < 0.00001, I2 = 96% | Random |
| Iodine-adequate | 11 | 1.73(1.27, 2.35) | =0.0005 | P < 0.00001, I2 = 99% | Random |
| Study type | |||||
| CS | 10 | 1.78 (1.28, 2.46) | =0.0005 | P < 0.00001, I2 = 99% | Random |
| CC | 3 | 2.31 (1.21,4.42) | =0.01 | P = 0.01, I2 = 95% | Random |
| Criteria | |||||
| IDF | 5 | 1.63 (1.39,1.92) | <0.00001 | P < 0.00001, I2 = 89% | Random |
| CDS | 2 | 1.50 (1.01, 2.23) | =0.04 | P = 0.07, I2 = 69% | Random |
| NCEP-ATPIII | 4 | 2.07 (1.39, 3.09) | =0.0004 | P < 0.00001, I2 = 92% | Random |
| AHA | 2 | 2.46 (1.22, 4.97) | =0.01 | P < 0.00001, I2 = 97% | Random |
CS, cross-sectional study; CC, case-control study; N, number of samples; M, male; F, female; NCEP-ATP III, National Cholesterol Education Program Adult Treatment Panel III; IDF, International Diabetes Federation; CDS, China Diabetes Society; AHA, American Heart Association.