Table 1.
Anti-maturation and anti-biofilm activities of 11 lichen compounds against Candida albicans expressed as 50% inhibitory concentration (p < 0.05) at 24 and 48 h of treatment. IC50 is expressed in micromolar for values <100 µg/ml.
| Compounds | Anti-maturation activity | Anti-biofilm activity | ||
|---|---|---|---|---|
| MMIC50 | MBIC50 | |||
| µg/ml (µM) | µg/ml (µM) | |||
| 24 h | 48 h | 24 h | 48 h | |
| 1 | 100 | 6.25 (18) | 200 | 12.5 (37.5) |
| 2 | 50 (128) | 12.5 (32) | >200 | >200 |
| 3 | 50 (120) | 12.5 (30) | >200 | >200 |
| 4 | >200 | >200 | >200 | >200 |
| 5 | >200 | 100 | >200 | >200 |
| 6 | >200 | >200 | >200 | >200 |
| 7 | nd | nd | >200 | >200 |
| 8 | 200 | 200 | >200 | >200 |
| 9 | >200 | >200 | >200 | >200 |
| 10 | >200 | 100 | >200 | 100 |
| 11 | >200 | >200 | >200 | >200 |
These experiments were performed in triplicate with at least two replicate experiments.