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. 2021 Sep 16;12:662497. doi: 10.3389/fneur.2021.662497

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Copyright © 2021 Yang, Cheng, Wang, Upreti, Cui, Liu, Shan, Yu, Luo and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brain regions where the cortical thickness are different between gout patients and HCs. Cluster of areas with significantly thicker cortex in gout patients, including the left postcentral, left supramarginal, right medial temporal, and right medial orbitofrontal regions. Cluster of areas with significantly thinner cortex in gout patients including the left insula, left superior frontal, right pericalcarine, and right precentral regions (GRF correction, voxel level p < 0.05, cluster level p < 0.01). Cluster with p < 0.01 are shown in the figure. CT, cortical thickness; HCs, healthy controls; L, left; R, right; GRF, Gaussian random field.