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. 2021 Sep 16;12:662497. doi: 10.3389/fneur.2021.662497

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Copyright © 2021 Yang, Cheng, Wang, Upreti, Cui, Liu, Shan, Yu, Luo and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global network measures of two groups and between-group differences in these measures. Clustering coefficient (A,B), characteristic path length (C,D), gamma (E,F), lambda (G,H), small-world index (I,J), global efficiency (K,L), transitivity (M,N), and modularity (O,P) of the Gout and HC networks. The red * lying outside the confidence intervals indicates that the difference between the two groups in this density is significant (B,D,F,H,G,L,N,P). Except for a few densities, the global efficiency of HCs is lower than that of the gout group (p < 0.05, FDR-corrected; L); the rest of the abovementioned measures were not significantly different between the two groups. Gout, gout group; HCs, healthy controls; FDR, false discovery rate.