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. 2021 Sep 16;12:752148. doi: 10.3389/fphar.2021.752148

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Copyright © 2021 Pi, Jiang, Ding, Lai, Yang, Zhu, Guo, Fan, Chi and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alcohol withdrawal rescues alcohol-stimulated TLR4/MAPKs and mitochondrial apoptotic pathways. Total cellular lysates were extracted from mice liver tissues. (A, B) Immunoblotting assay was performed for TLR-4, p-JNK, p-P38, and p-ERK1/2. (C, D) Immunoblotting assay was performed for P53 and Bax/Bcl-2. *p < 0.05 indicates statistically significant differences (n = 8).