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. Author manuscript; available in PMC: 2021 Sep 30.
Published in final edited form as: Biol Chem. 2008 Mar;389(3):243–255. doi: 10.1515/BC.2008.022

Figure 1. Oxidative stress-activated pathways influencing TTR-RBP activity.

Figure 1

Green boxes: effector kinases in signaling cascades activated or repressed by oxidative stress. Yellow ovals: TTR-RBPs that are downstream of the effector kinases, either as direct phosphorylation substrates (solid arrow) or as indirect effectors (discontinuous arrow). ‘?’, evidence of phosphorylation available only from in vitro studies. Phosphorylated residues (threonines and serines) are indicated below the oval and phosphorylation linked to association with 14–3-3 (orange) is shown. Blue squares: changes in subcellular localization, association with cellular compartments (SGs, exosome) or binding to target mRNAs following modification of TTR-RBPs by the signaling cascades. Black boxes: consequences of TTR-RBP/RNP modifications upon the expression and translation of the mRNA.