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. 2021 Sep 16;9:730925. doi: 10.3389/fbioe.2021.730925

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Copyright © 2021 Zhong, Bejjanki, Miao, Weng, Li, Zhang, Liu, Vannam and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prussian blue staining (A) and Hoechst staining (B) (C) of different formations under various conditions. #Stands for p < 0.05 ASA@SPION versus FA-PEG@SPION. $ Stands for p < 0.05 ASA@SPION versus FA-PEG/CBT@SPION. * Stands for p < 0.05 FA-PEG@SPION versus FA-PEG/CBT@SPION. & Stands for p < 0.05 ICG versus FA-PEG/CBT@SPION-ICG. TEM results of HNE-1 cells after cellular uptake of FA-PEG@SPION-ICG and FA-PEG/CBT@SPION-ICG (D). Multimodal small animal imaging after injection of different formations at 8 h (E).