Table 2.
Individual clinical findings of patients with BRAIN metastases from DTC.
| Patient (years At BM diagnosis) | Sex | Pathology | Age at BM diagnosis(years) | PS (ECOG) at BM diagnosis | Interval years | Coexistent distant Metastasis | Location of BM/Numbers of the lesion (size) | Neurosurgery or not | Overall survival (months) | Other Treatment |
|---|---|---|---|---|---|---|---|---|---|---|
| Patient1 (2002) | Male | unknown | 65 | 1 | synchronous | lung, bone | Intracranial/M(2cm×3cm) | NO | 13(death) | WBRT+CT |
| Patient2 (2004) | Male | P | 54 | 0 | 2 | lung, bone | IntracranialM(3cm×2cm) | NO | 19(death) | SRS+WBRT+RAIT+CT |
| Patient3 (2005) | Male | P | 52 | 2 | 1 | lung, bone | Skull/S(3.8cm×5.5cm) | YES | 34(death) | SRS+RAIT+CT |
| Patient4 (2007) | Female | F | 68 | 4 | synchronous | NO | Intracranial/M(3cm×2cm) | NO | 1(death) | Palliative CT |
| Patient5 (2008) | Male | P | 56 | 0 | 4 | lung, bone, liver | Skull/M(2.6cm×2.1cm) | YES | 52(death) | WBRT+CT |
| Patient6 (2009) | Male | F | 45 | 1 | synchronous | lung | Skull/S(5cm×5cm) | YES | 60(death) | RT+RAIT |
| Patient7 (2010) | Male | P | 70 | 3 | 0.5 | lung, skin (foot) | Intracranial/M(2cm×1.5cm) | NO | 3(death) | SRS+Palliative CT |
| Patient8 (2014) | Female | P | 42 | 1 | synchronous | lung | Intracranial/M(1.7cm×1.5cm) | YES | 24(death) | Sorafeni |
| Patient9 (2014) | Male | F | 45 | 3 | 0.5 | lung | Intracranial/M(0.6cm×0.8cm) | NO | 10(death) | CT |
| Patient10 (2014) | Male | F | 60 | 3 | 10 | NO | Intracranial/S(2cm×2cm) | YES | 1(death) | Palliative CT |
| Patient11 (2015) | Female | unknown | 53 | 1 | synchronous | NO | Skull/S(2cm×2cm) | NO | 46(Alive) | RAIT |
| Patient12 (2015) | Female | P | 41 | 1 | synchronous | NO | Intracranial/S(2cm×2.6cm) | YES | 25(death) | RT+RAIT |
| Patient13 (2016) | Female | P | 75 | 3 | 20 | lung | Intracranial/M(2cm×2.1cm) | NO | 5(death) | Palliative RT |
| Patient14 (2017) | Male | P | 27 | 1 | 3 | lung | Skull/S(4cm×4cm) | NO | 30(Alive) | PD-1+RAIT |
| Patient15 (2017) | Female | P | 48 | 2 | synchronous | NO | Intracranial/M(2cm×2.1cm) | YES | 36(Alive) | SRS+RT+RAIT |
| Patient16 (2017) | Male | P | 56 | 2 | synchronous | lung | Intracranial/S(2cm×2 cm) | YES | 12(death) | RT+CT |
| Patient17 (2018) | Male | F | 42 | 1 | synchronous | lung | Intracranial/S(2cm×2 cm) | YES | 28(Alive) | RAIT |
| Patient18 (2018) | Female | F | 66 | 2 | synchronous | NO | Intracranial/S(4cm×3 cm) | YES | 24(Alive) | RT |
| Patient19 (2019) | Female | P | 39 | 1 | synchronous | NO | Intracranial/S(1cm×1 cm) | YES | 16(Alive) | RT |
| Patient20 (2019) | Female | P | 55 | 1 | 12 | bone | Intracranial/S(3cm×3 cm) | YES | 16(Alive) | RT+RAIT |
| Patient21 (2019) | Male | P | 76 | 2 | 5 | NO | Intracranial/M(3.4cm×3.5 cm) | NO | 10(Alive) | Palliative RT |
| Patient22 (2020) | Female | P | 55 | 1 | 6 | lung, bone | Intracranial/S(2.5 cm×3.5 cm) | YES | 6(Alive) | Sorafeni |
P, papillary; F, follicular; PS, performance status; BM, brain metastasis; CT, chemotherapy; WBRT, whole brain radiotherapy treatment; RT, radiotherapy treatment; RAIT, Radioiodine Therapy; M, multitude; S, single.