Table 3.
Kaplan-Meier (Log-Rank Test) and Multiple Cox Regression Analysis of Prognostic Factors for 22 Patients with Brain Metastases of DTC.
| Factors | Numbers of patients | OS (months)(median ± 95%CI) | P (K-M) | P(COX) |
|---|---|---|---|---|
| Sex | ||||
| Male | 13 | 24.2 ± 6.2 | 0.096 | 0.651 |
| Female | 9 | 42.4 ± 7.8 | ||
| Pathological | ||||
| Papillary | 13 | 31.4 ± 5.7 | 0.874 | |
| Follicular | 7 | 21.6 ± 10.6 | ||
| Thyroid operation | ||||
| No | 6 | 28.8 ± 7.0 | 0.976 | |
| Yes | 16 | 30.1 ± 6.1 | ||
| Neurosurgery | ||||
| No | 11 | 18.41 ± 5.8 | 0.030 | 0.501 |
| Yes | 11 | 40.6 ± 5.9 | ||
| Other distance | ||||
| No | 8 | 29.5 ± 7.2 | 0.558 | |
| Yes | 14 | 28.8 ± 5.9 | ||
| Symptom | ||||
| No | 7 | 32.3 ± 5.7 | 0.499 | |
| Yes | 15 | 29.0 ± 6.4 | ||
| Age(years) | ||||
| ≤55 | 14 | 37.2 ± 5.6 | 0.055 | 0.862 |
| >55 | 8 | 13.4 ± 4.5 | ||
| Radiotherapy Treatment | ||||
| No | 10 | 26.0 ± 6.3 | 0.606 | |
| Yes | 12 | 33.0 ± 6.4 | ||
| Radioiodine Therapy | ||||
| No | 11 | 23.64 ± 5.6 | 0.272 | |
| Yes | 11 | 36.6 ± 6.8 | ||
| Lesions site | ||||
| Intracranial | 17 | 17.6 ± 2.7 | 0.015 | 0.935 |
| Skull | 5 | 51.6 ± 4.5 | ||
| Lesions number | ||||
| Single | 13 | 37.1 ± 6.0 | 0.084 | 0.111 |
| Multiple | 9 | 18.3 ± 6.3 | ||
| PS | ||||
| <2 | 8 | 38.7 ± 5.4 | 0.004 | 0.007 |
| ≥2 | 14 | 8.5 ± 2.3 |