Table 2.
Afamin correlates with parameters of obesity, insulin resistance & physical activity.
| Afamin adjusted for age | |||||
|---|---|---|---|---|---|
| r | p | r | p | N | |
| Age | 0.366 | <0.01 | 71 | ||
| Obesity | |||||
| Atherogenic index | 0.589 | <0.0001 | 0.419 | <0.001 | 69 |
| BMI | 0.529 | <0.0001 | 0.419 | <0.001 | 71 |
| Body fat % | 0.526 | <0.0001 | 0.428 | <0.001 | 68 |
| Fat cell size | 0.519 | <0.0001 | 0.392 | <0.01 | 67 |
| Waist circumference | 0.513 | <0.0001 | 0.409 | <0.001 | 69 |
| Fasting triglycerides | 0.485 | <0.0001 | 0.396 | <0.001 | 70 |
| Body weight | 0.458 | <0.0001 | 0.379 | <0.01 | 71 |
| hsCRP | 0.444 | <0.001 | 0.377 | <0.01 | 67 |
| Visceral AT | 0.431 | <0.001 | 0.251 | <0.05 | 64 |
| Subcutaneous AT | 0.401 | <0.01 | 0.305 | <0.05 | 64 |
| Fasting free fatty acids | 0.312 | <0.01 | 0.280 | <0.05 | 70 |
| Systolic blood pressure | 0.206 | >0.05 | 0.193 | >0.05 | 58 |
| Fasting cholesterol | 0.214 | >0.05 | 0.108 | >0.05 | 70 |
| LDL cholesterol | 0.163 | >0.05 | 0.053 | >0.05 | 69 |
| Liver parameters | |||||
| Hepatic lipid content | 0.721 | <0.0001 | 0.595 | <0.0001 | 60 |
| GGT | 0.656 | <0.0001 | 0.567 | <0.0001 | 70 |
| Fatty liver index | 0.655 | <0.0001 | 0.536 | <0.0001 | 68 |
| ALT | 0.528 | <0.0001 | 0.496 | <0.0001 | 70 |
| AST | 0.330 | <0.01 | 0.320 | <0.01 | 69 |
| Diabetes | |||||
| HOMA-IR | 0.674 | <0.0001 | 0.600 | <0.0001 | 70 |
| Fasting Insulin | 0.646 | <0.0001 | 0.616 | <0.0001 | 70 |
| M-value/Ins* | -0.632 | <0.0001 | -0.560 | <0.0001 | 70 |
| Fasting C-peptide | 0.614 | <0.0001 | 0.516 | <0.0001 | 69 |
| Insulinemia AUC (oGTT) | 0.593 | <0.0001 | 0.599 | <0.0001 | 61 |
| Serum adiponectin | -0.536 | <0.0001 | -0.478 | <0.001 | 48 |
| Fasting glycemia | 0.473 | <0.0001 | 0.291 | <0.05 | 71 |
| C-peptide AUC (oGTT) | 0.417 | <0.001 | 0.389 | <0.01 | 61 |
| Glycemia AUC (oGTT) | 0.396 | <0.01 | 0.273 | <0.05 | 62 |
| FFA-EHC** | 0.346 | <0.01 | 0.365 | <0.01 | 69 |
| Physical activity | |||||
| Steps number/24h | -0.268 | <0.05 | -0.327 | <0.05 | 60 |
| Sport index | -0.267 | <0.05 | -0.229 | >0.05 | 71 |
| Leisure-time index | -0.251 | <0.05 | -0.229 | >0.05 | 71 |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; AT, adipose tissue; AUC, area under the curve; BMI, body mass index; FFA-EHC, Free Fatty Acids measured in a steady state of the euglycemic hyperinsulinemic clamp/EHC; GGT, gamma-glutamyltransferase; HOMA-IR, HOMA insulin resistance index; hsCRP, high sensitivity C-reactive protein; M-value/Ins, insulin sensitivity normalized to steady state insulinemia, measured by EHC; Spearman correlation. *whole body insulin sensitivity, **adipose tissue-specific insulin sensitivity.