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. 2021 Sep 16;12:705646. doi: 10.3389/fimmu.2021.705646

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Copyright © 2021 Vázquez-Jiménez, Avila-Ponce De León, Matadamas-Guzman, Muciño-Olmos, Martínez-López, Escobedo-Tapia and Resendis-Antonio

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathway Enrichment Analysis across various databases. Activity status of the TFs in a particular pathway found by DoROthEA across the disease severity in Neutrophils. (A) GSEA in moderate patients. (B) GSEA in healthy controls. (C) GSEA in severe patients. The normalized enrichment score (NES) value represents the activity status within the disease severity conditions, a positive value for active pathways (red), and a negative value for inactive pathways (blue). The dataset for every pathway (rows) is indicated inside the colored bar.