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. 2021 Sep 16;12:705646. doi: 10.3389/fimmu.2021.705646

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Copyright © 2021 Vázquez-Jiménez, Avila-Ponce De León, Matadamas-Guzman, Muciño-Olmos, Martínez-López, Escobedo-Tapia and Resendis-Antonio

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathways and transcription factors dysregulated on epithelial cells among patients. (A) Changes in the pathways activation/inactivation identified by PROGENY analysis. White boxes indicate no change of the pathways in the group of patients respectively. (B) Transcription factors inferred by DoRothEA algorithm. Colorbar is related to activation/inactivation values. (C) Pathway Enrichment Analysis, the normalized enrichment score (NES) value represents the activity status within the disease severity conditions. Blue and red bars relate NES values for the moderate and severe patients, respectively.