Figure 3.

Macrophage progenitor cells are transiently decreased at 12-weeks of cigarette smoke exposure. Female C57BL/6 mice were RA or CS-exposed for 12-weeks. Data show total numbers of Ly6C^Lo and Ly6C^Hi monocyte populations in (A) lungs, (B) blood, (C) spleen, and (D) bone marrow. Shown in (E) total numbers of macrophage progenitor cells in the bone marrow (lineage-negative Sca1 c-Kit (LSK), monocyte-macrophage dendritic cell progenitor (MDP), common monocyte progenitor (cMoP)). Data show mean ± SEM, n = 5. Unpaired t test with Welch’s correction. RA, room air; CS, cigarette smoke. *p < 0.05