TABLE 2.

Changes of metabolites from baseline to 4-wk follow-up (Paired t test).

Metabolites	Regulation	Changes from baseline (95% CI)	p	Fold changes
LysoPE(20:5)	Up	28008 (10889, 45128)	0.002	0.92 (0.17, 1.35)
LysoPE(18:3)	Up	120565 (36447, 204683)	0.007	0.90 (0.01, 2.35)
LysoPE(16:1)	Up	34625 (15665, 63639)	0.001	1.001 (0.16, 3.09)
LysoPE(20:3)	Up	158801 (110956, 206645)	<0.001	1.36 (0.57,3.87)
LysoPE(22:5)	Up	332257 (199231, 465282)	<0.001	0.54 (0.17, 1.22)
LysoPE(18:2)	Up	1180553 (595466, 1765639)	<0.001	0.72 (0.22, 1.41)
LysoPE(22:1)	Down	−12508 (−18344, −6672)	<0.001	−0.5 (−0.86, −0.22)
LysoPE(22:6)	No change	−1022620 (−2116118, 70878)	0.07	−0.14 (−0.28, 0.10)
LysoPE(22:0)	Up	613281 (300488, 926074)	<0.001	0.55 (0.17, 1.56)
LysoPC(18:0)	Up	59496023 (28783987, 90208060)	0.001	0.17 (−0.08, 0.39)
LysoPC(22:6)	Down	-13073032 (-24702772, -1443292)	0.03	−0.15 (−0.45, 0.17)
LysoPC(20:3)	Up	37830985 (28049234, 47612735)	<0.001	0.98 (0.53, 1.54)
LysoPC(20:4)	No change	−437356 (−908067, 33353)	0.07	−0.14 (−0.30, 0.09)
LysoPC(15:0)	Up	2149849 (729001, 3570697)	0.005	0.30 (0.01, 0.46)
LysoPC(22:4)	Up	597175 (380502, 813847)	<0.001	1.26 (0.34, 1.88)
LysoPC(17:0)	Up	4130458 (1999412, 6261504)	0.001	0.43 (0.08, 10.9)
LysoPC(14:0)	Up	850540 (614758, 1086323)	<0.001	1.16 (0.65, 2.29)
LysoPC(16:1)	Up	1819062 (1271635, 2366489)	<0.001	0.81 (0.33, 1.23)
LysoPC(18:3)	Up	395471 (232238, 558705)	<0.001	0.63 (0.25, 1.40)
LysoPC(20:2)	Up	5180523 (3697696, 6663350)	<0.001	0.59 (0.39, 1.02)
LysoPC(22:2)	Up	32447 (19464, 45431)	<0.001	2.49 (1.45, 4.65)
LysoPC(18:1)	Up	6273223 (3923344, 8623102)	<0.001	0.25 (0.09, 0.45)

PC, phosphatidylcholine; PE, phosphatidylethanolamine; CI, confidence. Change refers to the levels of metabolites at follow-up minus the levels at baseline.