Figure 1. Comparison of the inhibitory effects of SAL on HSV1g infection when administered pre- or post-infection.

HCE cells were infected with HSV1g (HSV-1-H129 with GFP knock-in) at an MOI of 1.0. SAL (0.04 mg/mL) was added to the medium 12h before viral infection (upper panel) or 1h post-infection (lower panel); phase-contrast images and GFP fluorescence were obtained by microscopy under the same magnification (scale bar=50 µm). Both pre- and post-virus-infection, the addition of SAL to the culture medium resulted in substantial decreases in cell lesions and in HSV1g GFP expression.