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. Author manuscript; available in PMC: 2021 Sep 30.
Published in final edited form as: Biochem J. 2008 Jan 15;409(2):389–398. doi: 10.1042/BJ20070860

Figure 7. Proposed model depicting the role of cellular polyamines in modulating the subcellular localization of HuR through AMPK-regulated phosphorylation (P) and acetylation (Ac) of Imp-α1.

Figure 7

Increased polyamines result in AMPK activation that enhances the nuclear accumulation of HuR through a mechanism involving Impα1. The activation of AMPK by polyamines promotes Impα1-mediated nuclear import of HuR via modification of Impα1 on two residues. In addition, Impβ is also proposed to participate in the formation of HuR–Impα1 complexes for HuR nuclear import.