Table 2.
Other Zoster Vaccines and Zoster Vaccine Candidates
| Company Name | Country | Vaccine Name | Characteristics | Status | Reference |
|---|---|---|---|---|---|
| SK Bioscience | South Korea | SKY Zoster (NBP608) | Live-attenuated Oka/SK strain |
NCT03120364 Phase 3 (completed); approved in 2017 in Korea for adults ≥50 yoa |
Choi WS, Choi JH, Jung DS, et al [255] |
| Curevo/GC Pharma/IDRI | USA/South Korea | CRV-101 | gE subunit vaccine with proprietary adjuvant |
NCT03820414 Phase 1 (completed) |
https://curevovaccine.com/2020/09/curevo-vaccine-announces-robust-antibody-response-results-of-phase-i-clinical-trial-of-investigational-vaccine-for-shingles-crv-101/ |
| EyeGene/Novotech | South Korea/Australia | EG-HZ | Adjuvanted recombinant VZV gE protein |
NCT04210752 Phase 1 (completed) |
http://eyegene.co.kr/ eng/product_pipeline/EG_HZ/?lang = en_US |
| BCHT Biotechnology | China | Zoster Vaccine, Live | Live-attenuated Oka VZV vaccine |
NCT04334577 Phase 3 (not yet recruiting) |
https://ichgcp.net/clinical-trials-registry/ NCT04334577 |
| Vaccitech/ CanSino Biologics | United Kingdom/Hong Kong | VTP-400 (CSB016) | Adenoviral vaccine (ChAdOx1) encoding VZV gE | Preclinical | www.vaccitech.co.uk/pipeline/ |
| GeneOne Life Science | South Korea | GLS-5100 | plasmid containing VZV-derived gene encoding a VZV protein; administered to the body using electroporation | Preclinical | www.genels.com/en/sub/technology/ vaccine.asp |
| Akshaya Bio | Canada | Chimigen ShingVax | recombinant proteins, antigens fused to the Fc fragment of a murine monoclonal antibody through proprietary peptide linkers. | Preclinical | www.akshayabio.com/technology.html |
| Merck/Moderna | USA | VZV gE mRNA/LNP | mRNA expressing truncated VZV gE protein in lipid nanoparticles | Nonhuman primate studies | Monslow MA, Elbashir S, Sullivan NL, et al [260] |
| CPL Biologicals | India | VZV Vaccine | Based on nanoparticle technology from Novavax (will target varicella and HZ) | In development | http://cplbio.com/rd/rd-pipeline/ |
Abbreviations: gE, glycoprotein E; HZ, herpes zoster; IDRI, Infectious Disease Research Institute; LNP, lipid nanoparticle(s); mRNA, messenger ribonucleic acid; VZV, varicella-zoster virus; yoa, years of age.