Table 2.

Summary of differentially expressed miRNAs with their validated targets in gonadotrophinomas.

miRNA	Expression Levels	miRNA Profiling Platform	Biological Function	Target Genes	Reference
miR-145, miR-53, and miR-374	/ 1	RNA-sequencing	Contribute to tumor development	DEGs 2 mainly enriched in cell cycle and neuroactive ligand-receptor interaction	[47]
miR-15a, miR-15b, and miR-16	↓	qPCR	Contributes to pituitary tumorigenesis	HMGA1 and HMGA2	[49]

¹ / Data not reported; ² differentially expressed genes.