Table 3.

Summary of differentially expressed miRNAs with their validated targets in prolactinomas.

miRNA	Expression Levels	miRNA Profiling Platform	Biological Function	Target Genes	Reference
miR-7a2	/ 1	qPCR	Regulates prolactin production	Raf1	[50]
miR-93	↑	qPCR	Mediates CAB resistance	ATG7	[51,52]
miR-93-5p	↑	RNA-sequencing, PCR	Regulates TGF-β1/Smad3 signaling-mediated fibrosis	Smad7	[53]
miR-1299	↑	RNA-sequencing, qPCR	Regulates PRL gene transcription participating in the drug resistance	FOXO1	[54]
miR-145-5p	↓	qPCR	Regulates drug resistance	TPT1	[55]
miR-130a-3p	↓	Microarray, qPCR	Role in prolactin regulation	ERα	[56]
miR-137	↓	Microarray, qPCR	Regulates Wnt-β-catenin signaling pathway	MITF	[57]

¹ / Data not reported.