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. 2021 Sep 3;7(3):55. doi: 10.3390/ncrna7030055

Table 8.

Summary of differentially expressed c-miRNAs in PAs.

Biological Fluid miRNA Expression Levels miRNA
Profiling
Platform		 Potential Use
as Biomarker		 Reference
Plasma miR-16-5p,
mir-145-5p,
and miR-7g-5p		 ↑ qPCR Distinguishing between CD 1 and EAS 2 patients [101]
Plasma miR-143-3p ↓ NGS, qPCR Patient FSH/LH+ follow up [102]
Serum miR-16 ↓ qPCR Correlation with longer OS 3 and DFS 4 in pituitary tumor patients [105]
Serum miR-423-5p ↓ Microarray, NGS, qPCR Clinical treatment of
somatotroph adenomas		 [106]

1 Cushing’s disease; 2 ectopic ACTH secretion; 3 overall survival; 4 disease-free survival.