Table 1.
Demographics, clinical characteristics, and outcomes of patients with COVID-19 on invasive mechanical ventilation with necrotizing pneumonia.
| Hospital n (%) | |
|---|---|
| Hospital Pablo Tobón Uribe (HPTU) | 35 (83.3) |
| Clinica Cardiovid (CCV) | 7 (16.7) |
| Mean age—years (SD) | 61 ± 13 |
| Male sex n (%) | 35 (83.3) |
| Year of admission n (%) | |
| 2020 | 20 (47.6) |
| 2021 | 22 (52.4) |
| Median days from first symptom to dx (IQR) | 27 (22–32) |
| Median days of IMV to dx (IQR) | 15.5 (11–23) |
| Comorbidities n (%) * | |
| Obesity | 17 (40.5) |
| Hypertension | 16 (38.1) |
| Diabetes | 12 (28.6) |
| Current/former smoker | 8 (19.0) |
| Immunosuppression | 4 (9.52) |
| CKD | 2 (4.76) |
| COPD | 1 (2.38) |
| CAD | 1 (2.38) |
| No comorbidities | 9 (21.43) |
| Etiology n (%) | |
| K. pneumoniae | 24 (57.14) |
| P. aeruginosa | 14 (33.33) |
| S. marcescens | 5 (11.9) |
| P. mirabilis | 4 (9.52) |
| MSSA | 3 (7.14) |
| B. cepacia | 2 (4.76) |
| MRSA | 1 (2.38) |
| E. cloacae | 1 (2.38) |
| Candida, Aspergillus spp., or other molds (%) | 8 (19.0) |
| Bacteria isolated ≥ 2 times n (%) | 28 (66.67) |
| MIC creep n (%) | 11 (26.19) |
| Associated bacteremia n (%) | 12 (30) |
| Polymicrobial etiology n (%) | 22 (52.38) |
| Median antibiotic days prior to dx (IQR) | 13 (7–17) |
| Clinical findings | |
| Median D Dimer at admission (IQR) ng/mL | 1329 (713–3621) |
| Mean LDH at admission U/L | 541.81 ± 197.57 |
| Median PaFiO2 ratio at dx (IQR) | 138.5 (118–172) |
| Mean WBC count at dx cells/mm3 (SD) | 14161 ± 4845 |
| Median lymphocyte count at dx cells/mm3 (IQR) | 803.5 (500–1100) |
| Mean CRP at dx mg/dl (SD) | 20.06 ± 9.43 |
| Imaging and/or surgical findings n (%) * | |
| Abscess | 21 (50.0) |
| Mediastinal/hilar adenopathies | 20 (47.62) |
| Cavity | 17 (40.48) |
| Pneumatocele | 16 (38.1) |
| Pneumothorax | 15 (35.71) |
| Pulmonary embolism | 13 (30.95) |
| Bronchopleural fistula | 11 (26.19) |
| Empyema | 9 (21.43) |
| Pulmonary infarction | 8 (19.05) |
| Surgical/drainage procedure n (%) * | 19 (45.24) |
| Percutaneous drainage n (%) | 10 (23.81) |
| Decortication n (%) | 10 (23.81) |
| Lobectomy n (%) | 9 (21.43) |
| Median number of procedures per patient (IQR) | 1 (1–2) |
| Outcome n (%) | |
| Death (overall) | 24 (57.14) |
| Death (excluding patients still admitted) | 24 (70.58) |
| Median days from dx to death (IQR) | 37 (23.5–43) |
| Hospital discharge | 10 (23.81) |
Table 1 Legend. SD: standard deviation; n: number; dx: diagnosis; IQR: interquartile range; IMV: invasive mechanical ventilation; COPD: chronic obstructive pulmonary disease; CKD: chronic kidney disease; CAD: coronary artery disease; K. pneumoniae: Klebsiella pneumoniae; P. aeruginosa: Pseudomonas aeruginosa; S. marcescens: Serratia marcescens; P. mirabilis: Proteus mirabilis; MSSA: methicillin-sensitive Staphylococcus aureus; MRSA: methicillin-resistant Staphylococcus aureus; B. cepacia: Burkholderia cepacia; E. cloacae: Enterobacter cloacae; MIC: minimum inhibitory concentration; LDH: lactate dehydrogenase; PaFiO2 ratio of arterial oxygen partial pressure (PaO2 in mmHg) to fractional inspired oxygen (FiO2); WBC: white blood cell; CRP: C-reactive protein. * The sum may exceed 42 because each case may have had one or more of the characteristics in the list.