TABLE 3.
Citotoxicity (CC20 and CC50), antiviral potency (IC50) and antiviral Selectivity Index (SI) for warifteine, methylwarifteine and 6-MMPr for infection of Vero cells with ZIKV.
| dCC20 (μg/ml) | aCC50 (μg/ml) | bIC50 (μg/ml) | cSI | |
|---|---|---|---|---|
| Warifteine | 10.49 | 150.3 | 2.2 | 68.3 |
| Subfraction 6 | 7.89 | 21.49 | 3.5 | 6.14 |
| 6-MMPr | 60.5 | 291 | 24.5 | 11.9 |
a
CC50 (50% cytotoxic concentration) refers to compound concentration that caused a 50% reduction in viability.
b
IC50 (50% inhibitory concentration) refers to compound concentration required to reduce viral titres by 50% compared with untreated controls.
c
The Selectivity Index (SI) was calculated as the ratio of the CC50 to the IC50.
d
CC20 (20% cytotoxic concentration) was taken as the non-toxic concentration to be employed in the antiviral assays.
Results are mean values of 3 independent experiments.