1 |
1–4 layers |
Non-dense, mature fibrous tissue |
Fibroblast without macrophages or foreign body cells |
Dense, mature interstitial tissue, similar to a normal connective or adipose tissue |
2 |
5–9 layers |
Immature fibrous tissue with fibroblasts and little collagen |
Isolated foci or macrophages or foreign body cells |
Interstitial tissue with blood vessels, fibroblasts, and a few macrophages |
3 |
10–30 layers |
Dense granular tissue with fibroblasts and many inflammatory cells |
One layer of macrophages foreign body cells |
Interstitial tissue with giant inflammatory cells but with permeating connective tissue |
4 |
>30 layers |
Mass of inflammatory cells, with disorganized connective tissue |
Multiple layers of macrophages and foreign body cells |
Mass of inflammatory cells without permeating connective tissue |