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. 2021 Sep 29;78(11):1–12. doi: 10.1001/jamapsychiatry.2021.2099

Table. Association Results With Depression for Novel Loci With P < 5 x 10−8 Based on Fixed-Effects Meta-analyses.

rs-ida CHR:position EA/OA Cohort No. of individuals with depression; No. of control participants EAF β (SE) OR (95% CI)b P value
Discovery set: East Asian ancestry GWAS of broad depression
rs4656484 1:166145466 C/G EASc 15 771; 178 777 0.63 −0.018 (0.003) 0.94 (0.91-0.97) 4.43×10−8
EURd 170 756; 329 443 0.76 −0.003 (0.005) 1.00 (0.99-1.01) .53
Discovery set: studies conducted in East Asian countries
rs10240457 7:15431149 A/G East Asiae 12 027; 83 727 0.65 0.028 (0.005) 1.08 (1.05-1.12) 6.48×10−9
EURd 170 756; 329 443 0.50 −0.005 (0.004) 1.00 (0.99-1.00) .28
Discovery set: meta-analysis combining ancestrally East Asian and European samples
rs7548487 1:177025098 A/G EAS+EURf 186 527; 508 220 0.90 −0.013 (0.002) 0.96 (0.95-0.98) 1.29×10−8
EASc 15 771; 178 777 0.95 −0.016 (0.007) 0.95 (0.89-1.01) .02
EURd 170 756; 329 443 0.88 −0.035 (0.007) 0.97 (0.96-0.97) 1.26×10−7
rs547488 18:26481463 C/G EAS+EURf 186 527; 508 220 0.54 0.008 (0.001) 1.02 (1.01-1.03) 3.25×10−8
EASc 15 771; 178 777 0.78 0.011 (0.004) 1.05 (1.01-1.08) .003
EURd 170 756; 329 443 0.45 0.020 (0.004) 1.02 (1.01-1.03) 3.12×10−6
rs12160976 22:46438246 A/G EAS+EURf 186 527; 508 220 0.25 −0.009 (0.002) 0.98 (0.97-0.98) 1.55×10−8
EASc 15 771; 178 777 0.02 −0.026 (0.011) 0.91 (0.81-1.03) .02
EURd 170 756; 329 443 0.34 −0.024 (0.005) 0.98 (0.97-0.99) 2.40×10−7

Abbreviations: CHR, chromosome; EA, effect allele; EAF, effect allele frequency; EAS, East Asian descent; EUR, European descent; OA, other allele; OR, odds ratio.

a

Only the lead variant of each locus is included. The association results for these variants in European ancestry samples from the largest published meta-analysis for depression are also shown.7

b

Based on an inverse-variance–weighted meta-analysis of the regression coefficients for EAS and EAS+EUR.

c

East Asian ancestry GWAS of broad depression outcome.

d

Published results from depression GWAS with European ancestry samples.

e

Depression GWAS restricted to studies conducted in East Asian countries.

f

Meta-analysis between East Asian GWASc and European ancestry GWAS.d