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Dose-response curves of the six ACE2-binding compounds in PP and CTG assays. (a) Compound 1, (b) compound 2, (c) compound 5, (d) compound 24, (e) compound 25, and (f) compound 19. WT—wild-type SARS-CoV-2 variant assay; SA—South African B.1.351 variant assay; UK—UK B.1.1.7 variant assay; VSV-G—PP assay containing the G-protein of vesicular stomatitis virus; and Tox—cytotoxicity assay.
