Table 3. Univariate and multivariate RFS and OS analysis of 228 patients with N0 stage.
| Variables | RFS | OS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | ||||
| Age, years (≥60 vs. <60) | 1.068 (0.570–2.001) | 0.837 | 6.144 (2.755–13.70) | <0.001 | 5.988 (1.757–20.41) | 0.004 | |||||
| Gender (male vs. female) | 1.038 (0.553–1.950) | 0.907 | 1.726 (0.772–3.858) | 0.181 | |||||||
| Smoking history (ever vs. never) | 1.419 (0.718–2.804) | 0.285 | 1.959 (0.819–4.683) | 0.094 | |||||||
| Radiologic component (solid vs. part-solid) | 4.915 (2.593–9.318) | <0.001 | 4.734 (2.117–10.59) | <0.001 | 4.926 (1.821–13.33) | 0.002 | |||||
| Surgical procedure (LOB vs. SEG/WED) | 3.937 (1.342–11.55) | 0.143 | 0.500 (0.124–2.011) | 0.195 | |||||||
| Histologic subtype (high vs. intermediate) | 1.636 (0.459–5.827) | 0.345 | 2.581 (0.549–12.14) | 0.071 | |||||||
| Pathological tumor size (T1b vs. T1a) | 1.099 (0.473–2.552) | 0.830 | 1.339 (0.451–3.982) | 0.633 | |||||||
| VPI (present vs. absent) | 1.334 (0.508–3.506) | 0.508 | 3.190 (0.991–10.27) | 0.004 | 0.109 | ||||||
| LVI (present vs. absent) | 1.874 (0.396–8.868) | 0.285 | 5.369 (0.807–35.74) | <0.001 | 3.257 (1.179–9.009) | 0.023 | |||||
| EGFR mutation (yes vs. no) | 0.724 (0.372–1.407) | 0.316 | 0.375 (0.162–0.871) | 0.013 | 0.263 | ||||||
RFS, recurrence-free survival; OS, overall survival; LOB, lobectomy; SEG, segmentectomy; WED, wedge; VPI, visceral pleural invasion; LVI, lymphovascular invasion; EGFR, epidermal growth factor receptor.