Table 4. Univariate and multivariate RFS and OS analysis of 258 patients with APA/PPA/IMA.
| Variables | RFS | OS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | ||||
| Age, years (≥60 vs. <60) | 1.174 (0.719–1.917) | 0.522 | 3.467 (1.906–6.307) | <0.001 | 3.268 (1.565–6.849) | 0.002 | |||||
| Gender (male vs. female) | 1.016 (0.620–1.666) | 0.948 | 1.519 (0.831–2.777) | 0.167 | |||||||
| Smoking history (ever vs. never) | 1.154 (0.675–1.973) | 0.589 | 1.791 (0.925–3.469) | 0.055 | |||||||
| Radiologic component (solid vs. part-solid) | 4.834 (2.954–7.912) | <0.001 | 3.096 (1.590–6.024) | 0.001 | 6.279 (3.453–11.42) | <0.001 | 4.184 (1.650–10.64) | 0.003 | |||
| Surgical procedure (LOB vs. SEG/WED) | 2.612 (1.046–6.523) | 0.164 | 0.795 (0.256–2.466) | 0.659 | |||||||
| Pathological tumor size (T1b vs. T1a) | 1.186 (0.591–2.379) | 0.649 | 1.235 (0.523–2.924) | 0.656 | |||||||
| N-stage (N1–2 vs. N0) | 5.632 (2.707–11.72) | <0.001 | 3.509 (2.049–6.024) | <0.001 | 5.060 (2.344–10.92) | <0.001 | 2.985 (1.553–5.747) | 0.001 | |||
| VPI (present vs. absent) | 1.963 (0.958–4.023) | 0.019 | 0.452 | 1.961 (0.876–4.388) | 0.039 | 0.894 | |||||
| LVI (present vs. absent) | 2.261 (0.971–5.264) | 0.009 | 0.304 | 2.806 (1.123–7.012) | 0.001 | 0.674 | |||||
| EGFR mutation (yes vs. no) | 0.953 (0.563-1.613) | 0.857 | 0.470 (0.246-0.897) | 0.011 | 0.107 | ||||||
RFS, recurrence-free survival; OS, overall survival; APA, acinar pattern-predominant adenocarcinoma; PPA, papillary pattern-predominant adenocarcinoma; IMA, invasive mucinous adenocarcinoma; LOB, lobectomy; SEG, segmentectomy; WED, wedge; VPI, visceral pleural invasion; LVI, lymphovascular invasion; EGFR, epidermal growth factor receptor.