Table 5. Univariate and multivariate RFS analysis of 246 patients with pT1b.
| Variables | RFS | OS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | ||||
| Age, years (≥60 vs. <60) | 1.121 (0.683–1.840) | 0.653 | 3.151 (1.776–5.593) | <0.001 | 2.976 (1.477–5.988) | 0.002 | |||||
| Gender (male vs. female) | 1.052 (0.639–1.732) | 0.842 | 1.561 (0.875–2.786) | 0.123 | |||||||
| Smoking history (ever vs. never) | 1.077 (0.624–1.860) | 0.786 | 1.696 (0.889–3.234) | 0.073 | |||||||
| Radiologic component (solid vs. part-solid) | 5.610 (3.423–9.195) | <0.001 | 3.745 (1.808–7.752) | <0.001 | 7.621 (4.299–13.51) | <0.001 | 5.076 (1.905–13.51) | 0.001 | |||
| Surgical procedure (LOB vs. SEG/WED) | 3.129 (1.337–7.321) | 0.093 | 1.411 (0.514–3.876) | 0.560 | |||||||
| Histologic subtype (high vs. intermediate) | 1.468 (0.586–3.678) | 0.333 | 2.857 (0.975–8.371) | 0.003 | 0.107 | ||||||
| N-stage (N1–2 vs. N0) | 4.890 (2.479–9.644) | <0.001 | 2.933 (1.721–5.000) | <0.001 | 4.715 (2.331–9.537) | <0.001 | 2.770 (1.497–5.128) | 0.001 | |||
| VPI (present vs. absent) | 1.893 (0.932–3.843) | 0.028 | 0.508 | 1.882 (0.877–4.037) | 0.045 | 0.807 | |||||
| LVI (present vs. absent) | 2.355 (1.093–5.077) | 0.003 | 0.585 | 3.420 (1.508–7.755) | <0.001 | 0.418 | |||||
| EGFR mutation (yes vs. no) | 0.730 (0.431–1.237) | 0.218 | 0.413 (0.224–0.763) | 0.002 | 0.056 | ||||||
RFS, recurrence-free survival; LOB, lobectomy; SEG, segmentectomy; WED, wedge; VPI, visceral pleural invasion; LVI, lymphovascular invasion; EGFR, epidermal growth factor receptor.