Table 2. The clinical and CT characteristic differences among AIS, MIA and IAC in the training data set.
| Parameter | AIS | MIA | IAC | Total | P value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | n | % | |||||
| Total | 76 | 22.1 | 135 | 39.2 | 133 | 38.7 | 344 | 100.0 | ||||
| Tumor biomarker | ||||||||||||
| CEA (ng/mL) | 0.993 | |||||||||||
| Normal | 75 | 22.1 | 133 | 39.2 | 131 | 38.6 | 339 | 98.5 | ||||
| Abnormal | 1 | 20.0 | 2 | 40.0 | 2 | 40.0 | 5 | 1.5 | ||||
| CYFRA21-1 (ng/mL) | 0.237 | |||||||||||
| Normal | 70 | 21.9 | 129 | 40.4 | 120 | 37.6 | 319 | 92.7 | ||||
| Abnormal | 6 | 24.0 | 6 | 24.0 | 13 | 52.0 | 25 | 7.3 | ||||
| SCC (ng/mL) | 0.712 | |||||||||||
| Normal | 70 | 20.9 | 132 | 39.4 | 130 | 38.8 | 335 | 97.4 | ||||
| Abnormal | 3 | 33.3 | 3 | 33.3 | 3 | 33.3 | 9 | 2.6 | ||||
| NSE (ng/mL) | 0.958 | |||||||||||
| Normal | 68 | 22.3 | 119 | 39.0 | 118 | 38.7 | 305 | 88.7 | ||||
| Abnormal | 8 | 20.5 | 16 | 41.0 | 15 | 38.5 | 39 | 11.3 | ||||
| CA19-9 (U/mL) | 0.289 | |||||||||||
| Normal | 76 | 22.4 | 134 | 39.4 | 130 | 38.2 | 340 | 98.8 | ||||
| Abnormal | 0 | 0.0 | 1 | 25.0 | 3 | 75.0 | 4 | 1.2 | ||||
| CT characteristic | ||||||||||||
| Size (mm) | <0.001 | |||||||||||
| <6 | 26 | 57.8 | 17 | 37.8 | 2 | 4.4 | 45 | 13.1 | ||||
| ≥6 and <8 | 30 | 33.7 | 52 | 58.4 | 7 | 7.9 | 89 | 25.9 | ||||
| ≥8 and <10 | 10 | 17.5 | 37 | 64.9 | 10 | 17.5 | 57 | 16.6 | ||||
| ≥10 | 10 | 6.5 | 29 | 19.0 | 114 | 74.5 | 153 | 44.5 | ||||
| Highest CT value (HU) | −602.6±93.3 | −507.7±138.0 | −416.1±121.2 | <0.001 | ||||||||
| Lobulation | <0.001 | |||||||||||
| Yes | 10 | 11.9 | 13 | 15.5 | 61 | 72.6 | 84 | 24.4 | ||||
| No | 66 | 25.4 | 122 | 46.9 | 72 | 27.7 | 260 | 75.6 | ||||
| Spiculation | <0.001 | |||||||||||
| Yes | 7 | 8.3 | 24 | 28.6 | 53 | 63.1 | 84 | 24.4 | ||||
| No | 69 | 26.5 | 111 | 42.7 | 80 | 30.8 | 260 | 75.6 | ||||
| Pleural indentation | <0.001 | |||||||||||
| Yes | 11 | 12.6 | 25 | 28.7 | 51 | 58.6 | 87 | 25.3 | ||||
| No | 65 | 25.3 | 110 | 42.8 | 82 | 31.9 | 257 | 74.7 | ||||
| Vacuole sign | <0.001 | |||||||||||
| Yes | 5 | 5.6 | 27 | 30.3 | 57 | 64.0 | 89 | 25.9 | ||||
| No | 71 | 27.8 | 108 | 42.4 | 76 | 29.8 | 255 | 74.1 | ||||
| Vessel (normal) | <0.001 | |||||||||||
| Yes | 56 | 18.0 | 125 | 40.2 | 130 | 41.8 | 311 | 90.4 | ||||
| No | 20 | 60.6 | 10 | 30.3 | 3 | 9.1 | 33 | 9.6 | ||||
| Vessel (abnormal) | <0.001 | |||||||||||
| Yes | 10 | 5.6 | 60 | 33.3 | 106 | 58.9 | 180 | 52.3 | ||||
| No | 66 | 40.2 | 71 | 43.3 | 27 | 16.5 | 164 | 47.7 | ||||
CT, computed tomography; AIS, adenocarcinoma in situ; MIA, minimally invasive adenocarcinoma; IAC, invasive adenocarcinoma; CEA, carcinoembryonic antigen; CYFRA21-1, cytokeratin 19 fragment; SCC, squamous cell carcinoma antigen; NSE, neuro-specific enolase; CA19-9, carbohydrate antigen 19-9; HU, Hounsfield unit.