Table 4.
Risk of stratification of NHADKD by abnormal rates of eight atherogenic factors.
| Abnormal lipid changes | n/N (%)▲ | Hierarchical risk analysis | ||||
|---|---|---|---|---|---|---|
| Simple DM | NHADKD | OR | 95%CI | z | p | |
| Increased total-Chol | ||||||
| ACR < 10 mg/gCr | 23/448 (5.1) | 17/69 (24.6) | 6.04 | 3.03–12.04 | 5.110 | <0.001 |
| ACR ⩾ 10 mg/gCr | 19/303 (6.3) | 26/95 (27.4) | 5.63 | 2.95–10.76 | 5.233 | <0.001 |
| Total | 42/751 (5.6) | 43/164 (26.2) | 5.80 | 3.61–9.33 | 7.521 | <0.001 |
| Increased triglyceride | ||||||
| ACR < 10 mg/gCr | 202/448 (45.1) | 39/69 (56.5) | 1.58 | 0.95–2.64 | 1.762 | 0.078 |
| ACR ⩾ 10 mg/gCr | 118/303 (38.9) | 34/95 (35.8) | 0.87 | 0.54–1.41 | 0.552 | 0.581 |
| Total | 320/751 (42.6) | 73/164 (44.5) | 1.15 | 0.82–1.63 | 0.446 | 0.656 |
| Decreased HDL-Chol | ||||||
| ACR < 10 mg/gCr | 83/448 (18.5) | 37/69 (53.6) | 5.09 | 2.99–8.64 | 6.016 | <0.001 |
| ACR ⩾ 10 mg/gCr | 39/303 (12.9) | 10/95 (10.5) | 0.80 | 0.38–1.66 | 0.606 | 0.545 |
| Total | 122/751 (16.2) | 47/164 (28.7) | 2.43 | 1.63–3.63 | 3.658 | <0.001 |
| Increased LDL-Chol | ||||||
| ACR < 10 mg/gCr | 89/448 (19.9) | 7/69 (10.1) | 0.46 | 0.20–1.03 | 1.891 | 0.059 |
| ACR ⩾ 10 mg/gCr | 83/303 (27.4) | 20/95 (21.1) | 0.71 | 0.41–1.23 | 1.227 | 0.220 |
| Total | 172/751 (22.9) | 27/164 (16.5) | 0.61 | 0.38–1.01 | 1.802 | 0.072 |
| Decreased ApoA1 | ||||||
| ACR < 10 mg/gCr | 74/448 (16.5) | 11/69 (15.9) | 0.96 | 0.48–1.91 | 0.120 | 0.905 |
| ACR ⩾ 10 mg/gCr | 43/303 (14.2) | 20/95 (21.1) | 1.61 | 0.89–2.91 | 1.589 | 0.112 |
| Total | 117/751 (15.6) | 31/164 (18.9) | 1.55 | 0.99–2.43 | 1.533 | 0.060 |
| Increased ApoB | ||||||
| ACR < 10 mg/gCr | 141/448 (31.5) | 29/69 (42.0) | 1.58 | 0.94–2.65 | 1.727 | 0.084 |
| ACR ⩾ 10 mg/gCr | 127/303 (41.9) | 42/95 (44.2) | 1.10 | 0.69–1.75 | 0.395 | 0.693 |
| Total | 268/751 (35.7) | 71/164 (43.3) | 1.38 | 0.98–1.94 | 1.823 | 0.068 |
| Increased homocysteine | ||||||
| ACR < 10 mg/gCr | 74/448 (16.5) | 40/69 (58.0) | 6.97 | 4.07–11.95 | 7.059 | <0.001 |
| ACR ⩾ 10 mg/gCr | 57/303 (18.8) | 76/95 (80.0) | 17.26 | 9.67–30.82 | 9.636 | <0.001 |
| Total | 131/751 (17.4) | 116/164 (70.7) | 11.43 | 7.78–16.82 | 12.387 | <0.001 |
| Increased Lip-PLA2 | ||||||
| ACR < 10 mg/gCr | 108/448 (24.1) | 10/69 (14.5) | 0.53 | 0.26–1.08 | 1.748 | 0.081 |
| ACR ⩾ 10 mg/gCr | 100/303 (33.0) | 33/95 (34.7) | 1.08 | 0.67–1.76 | 0.313 | 0.755 |
| Total | 208/751 (27.7) | 43/164 (26.2) | 0.84 | 0.57–1.24 | 0.384 | 0.701 |
Note. ▲n is the number of abnormal change for each indicator in this group after ACR stratification, and N is the total number of patients in this group after ACR stratification. Simple DM: simple diabetes mellitus (ACR < 30 mg/gCr); NHADKD: non-high albuminuria diabetic kidney disease; ACR: albumin to creatinine ratio; eGFR: estimated glomerular filtration rate; total-Chol: total cholesterol; HDL-Chol: high-density lipoprotein cholesterol; LDL-Chol: low-density lipoprotein cholesterol; ApoA1: apolipoprotein A1; ApoB: apolipoprotein B; Lip-PLA2: lipoprotein-associated phospholipase A2.