Table 4.
MMSE (subclass analysis)
| Variable | n | Baseline | ΔWeek 12 | ΔWeek 24 | |
|---|---|---|---|---|---|
| MMSE Sum score (score) | Placebo | 19 | 27.9 ± 1.1 | 0.6 ± 1.9 | 0.6 ± 1.5 |
| Active | 19 | 27.1 ± 1.6 | 1.7 ± 1.8 | 1.8 ± 1.9 | |
| p | 0.100 | 0.113 | 0.028* | ||
| MMSE Temporal orientation (score) | Placebo | 19 | 5.0 ± 0.0 | −0.1 ± 0.2 | 0.0 ± 0.0 |
| Active | 19 | 4.9 ± 0.3 | 0.1 ± 0.3 | 0.1 ± 0.3 | |
| p | 0.152 | 0.086 | 0.152 | ||
| MMSE Spatial orientation (score) | Placebo | 19 | 4.3 ± 0.7 | 0.3 ± 0.7 | 0.4 ± 0.8 |
| Active | 19 | 4.3 ± 0.7 | 0.5 ± 0.8 | 0.5 ± 0.8 | |
| p | 0.860 | 0.386 | 0.550 | ||
| MMSE Registration (score) | Placebo | 19 | 3.0 ± 0.0 | −0.2 ± 0.7 | 0.0 ± 0.0 |
| Active | 19 | 2.9 ± 0.2 | 0.0 ± 0.3 | 0.1 ± 0.2 | |
| p | 0.317 | 0.553 | 0.317 | ||
| MMSE Attention (score) | Placebo | 19 | 4.4 ± 0.7 | 0.5 ± 0.8 | 0.4 ± 0.6 |
| Active | 19 | 4.0 ± 1.0 | 0.6 ± 0.9 | 0.5 ± 1.4 | |
| p | 0.285 | 0.975 | 0.345 | ||
| MMSE Remote memory (score) | Placebo | 19 | 2.7 ± 0.6 | 0.1 ± 0.7 | 0.2 ± 0.5 |
| Active | 19 | 2.7 ± 0.6 | 0.2 ± 0.4 | 0.3 ± 0.6 | |
| p | 0.723 | 0.453 | 0.708 | ||
| MMSE Naming two objects (score) | Placebo | 19 | 2.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Active | 19 | 2.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | |
| p | 1.000 | 1.000 | 1.000 | ||
| MMSE Repeat (score) | Placebo | 19 | 1.0 ± 0.0 | −0.1 ± 0.2 | −0.1 ± 0.3 |
| Active | 19 | 0.8 ± 0.4 | 0.1 ± 0.5 | 0.1 ± 0.4 | |
| p | 0.037* | 0.179 | 0.188 | ||
| MMSE Stage command (score) | Placebo | 19 | 2.7 ± 0.5 | 0.1 ± 0.7 | 0.0 ± 0.6 |
| Active | 19 | 2.7 ± 0.5 | 0.0 ± 0.8 | 0.3 ± 0.5 | |
| p | 1.000 | 0.889 | 0.142 | ||
| MMSE Writing a complete sentence (score) | Placebo | 19 | 1.0 ± 0.0 | −0.1 ± 0.2 | 0.0 ± 0.0 |
| Active | 19 | 0.9 ± 0.2 | 0.1 ± 0.2 | 0.1 ± 0.2 | |
| p | 0.317 | 0.163 | 0.317 | ||
| MMSE Reading and obey (score) | Placebo | 19 | 0.9 ± 0.3 | −0.1 ± 0.2 | −0.1 ± 0.3 |
| Active | 19 | 0.8 ± 0.4 | 0.0 ± 0.3 | −0.1 ± 0.3 | |
| p | 0.636 | 0.574 | 1.000 | ||
| MMSE Copy the diagram (score) | Placebo | 19 | 0.9 ± 0.2 | 0.0 ± 0.0 | −0.1 ± 0.2 |
| Active | 19 | 0.8 ± 0.4 | 0.2 ± 0.4 | 0.1 ± 0.5 | |
| p | 0.297 | 0.075 | 0.179 |
Values are shown as mean ± SD. ΔWeek 12 and 24: change in value from baseline to week 12 and 24, respectively. Mann–Whitney U test was performed. *p<0.05 vs placebo group. MMSE, Mini-Mental State Examination.