FIG. 3.

Polypeptide sequence analysis of the PIF subunits. (A) Alignment of the amino acid sequences predicted from the ORFs of cloned cDNAs encoding p79^pif and p96^pif, aligned by using the GCG BESTFIT program. The highly conserved region which contains the KDWK motif discussed in the text and panel B is boxed. (B) Alignment of sequences from the most highly conserved domain of human p96^pif and p79^pif, with individual proteins or representative members of protein groups, obtained from the GenBank database. The alignment, obtained by using the Genetics Computer Group Pile-Up program, was refined manually. Residues identical in at least half of the compared sequences are shaded. The oval box indicates the highly conserved KDWK motif, and the smaller boxes indicate extended relationships between pairs of compared molecules. Full names, GenBank accession numbers, and references for these proteins are cited in the text.