Table 3.

Lead compounds

Compound	MW	Function	Primary assay IC50 (μM)	SNCA efficacy (%)	Curve class	Cytotox IC50 (μM)a	Cytotox efficacy (%)a	Cytotox curve class	ELISA IC50b	α-Synuclein reduction at 0.5 μM (WB) (%)c
NCGC00470280	400.6	Unknown	15.8	−60	−2.4	n/a	n/a	4	30 nM	82
NCGC00419055	276.3	Unknown	15.8	−85	−1.2	n/a	n/a	4	366 nM	29
NCGC00345809	473.3	Cdk/Crk Inhibitor	0.11	−74	−1.2	0.09	−42	−1.2	411 nM	n.d.d
NCGC00448911	421.4	Unknown	15.8	−66	−1.2	n/a	n/a	4	99 nM	67
NCGC00347278 (A-443654)	397.5	AKT inhibitor	0.25	−86	−1.1	0.89	−53	−1.2	89 nM	85

^aDesignated n/a for inactive cytotox curve class of 4.

^bSNCA triplicated human fibroblast cell line ND27760.

^cHEK-293 cells.

^dValue not determined.