Extended Data Fig. 10 |. The response of the four melanoma models to αPD-1 is similar to αCTLA-4.

a, Schematic of the in vivo study design. 1.0 ×10⁶ melanoma cells from each model were implanted subcutaneously into C57BL/6 syngeneic mice. When the tumors reached 50mm³, mice were randomized and treated with αPD-1 or isotype antibody as control every 3 days for a total of 3 doses. b, Tumor growth of the melanomas from the indicated models upon treatment with αPD-1 (red lines) or isotype control (blue lines). N = 10 per group. c, Kaplan-Meier survival curves from (b). A representative from two experiments is shown. Two-tailed P-value from Gehan-Breslow-Wilcoxon test is indicated (c).