Table 2.
Clinical diagnostic performance of NASBA, PCR and colloidal gold
| Parameter | NASBA | PCR | Colloidal gold |
|---|---|---|---|
| Sensitivity [% (95% CI)] | 92.00 (72.50–98.60) | 64.00 (42.62–81.29)* | 100.00 (83.42–100.00) |
| Specificity [% (95% CI)] | 95.00 (81.79–99.13) | 80.00 (63.86–90.39) | 82.50 (66.64–92.11) |
| Accuracy [%] | 93.85 | 73.85 | 89.23 |
| Positive likelihood ratio | 18.40 (4.74–71.39) | 3.20 (1.61–6.35) | 5.71 (2.92–11.20) |
| Negative likelihood ratio | 0.08 (0.02–0.32) | 0.45 (0.26–0.77) | 0.00 (0.00-NaN) |
| Positive predictive value [% (95% CI)] | 92.00 (72.50–98.60) | 66.67 (44.69–83.57) | 78.13 (59.56–90.06) |
| Negative predictive value [% (95% CI)] | 95.00 (81.79–99.13) | 78.05(61.97–88.89) | 100.00 (87.02–100.00) |
| Youden index | 0.87 | 0.44 | 0.83 |
| Kappa | 0.87 | 0.44 | 0.78 |
Best performance values are highlighted in bold. *P < 0.05 versus NASBA, colloidal gold