Table 1.
Adjusted odds ratios (OR), population attributable fractions (PAF) and 95% confidence intervals (CI) for HNSCC associated with tobacco, alcohol, family history of HNC, low BMI, Hr-HPV and at-risk occupations
| Risk factor | Cases | Controls | ||||||
|---|---|---|---|---|---|---|---|---|
| n | n | ORa | 95% CIa | ORb | 95% CIb | PAFb | 95% CIb | |
| Tobacco smoking | ||||||||
| Ever | 114 | 142 | 6.72 | (4.24–10.64) | 5.86 | (3.47–9.90) | 65.7% | (51.7–75.6) |
| Never | 30 | 263 | 1 | ref | 1 | ref | 1 | ref |
| Missing | 1 | 0 | ||||||
| Daily alcohol | ||||||||
| Ever | 96 | 112 | 4.95 | (3.24–7.58) | 3.03 | (1.85–4.95) | 44.3% | (27.3–57.3) |
| Never | 49 | 293 | 1 | ref | 1 | ref | 1 | ref |
| Missing | 0 | 0 | ||||||
| Family history of HNC | ||||||||
| Yes | 13 | 14 | 3.67 | (1.66–8.08) | 4.70 | (1.81–12.22) | 8.9% | (1.1–16.1) |
| No | 108 | 387 | 1 | ref | 1 | ref | 1 | ref |
| Missing | 24 | 4 | ||||||
| Body mass index | ||||||||
| BMI < 18.5 | 12 | 10 | 4.63 | (1.89–11.33) | 4.96 | (1.69–14.59) | 9.0% | (1.2–16.1) |
| BMI ≥ 18.5 | 110 | 391 | 1 | ref | 1 | ref | 1 | ref |
| Missing | 23 | 4 | ||||||
| Oral HPV Status | ||||||||
| Hr-HPV+ | 19 | 30 | 2.31 | (1.34–3.99) | 2.39 | (1.23–4.63) | 15.1% | (3.9–25.0) |
| Hr-HPV- | 73 | 277 | 1 | ref | 1 | ref | 1 | ref |
| Missing | 53 | 98 | ||||||
| At-risk occupational activity | ||||||||
| Ever | 56 | 87 | 2.08 | (1.37–3.17) | 2.78 | (1.66–4.66) | 24.7% | (12.1–35.5) |
| Never | 89 | 318 | 1 | ref | 1 | ref | 1 | ref |
| Missing | 0 | 0 | ||||||
French West Indies, 2013–2016
Analyses performed using imputed data (145 cases 405 controls)
aAdjusted for age, sex, and region (variables used for frequency matching)
bAdjusted for age, sex, region and all the risk factors in the table (ever tobacco, ever daily alcohol, Hr-HPV, low body mass index, family history of HNC and at-risk occupational activity)