Table. 2.
Odds ratios (95 % CI) for HUA according to continuous and tertiles of lipid ratios
| Crude model | Adjusted model | |||||
|---|---|---|---|---|---|---|
| Variables | N | Events, n (%) | OR (95 %CI) | P value | OR (95 %CI) | P value |
| TC/HDL-C ratio (Per 1 SD increase) | 14,227 | 6320 (44.42 %) | 1.37 (1.32, 1.43) | < 0.001 | 1.35 (1.28, 1.41) | < 0.001 |
| Tertiles of TC/HDL-C ratio | ||||||
| T1 (< 2.75) | 4,742 | 1795 (37.85 %) | Reference | Reference | ||
| T2 (2.75–4.12) | 4,742 | 2032 (42.85 %) | 1.23 (1.13, 1.34) | < 0.001 | 1.32 (1.20, 1.46) | < 0.001 |
| T3 (≥ 4.12) | 4,743 | 2493 (52.56 %) | 1.82 (1.68, 1.97) | < 0.001 | 1.78 (1.61, 1.97) | < 0.001 |
| P for trend | < 0.001 | < 0.001 | ||||
| TG/HDL-C ratio (Per 1 SD increase) | 14,227 | 6320 (44.42 %) | 1.26 (1.22, 1.30) | < 0.001 | 1.27 (1.23, 1.32) | < 0.001 |
| Tertiles of TG/HDL-C ratio | ||||||
| T1 (< 0.62) | 4,740 | 1773 (37.41 %) | Reference | Reference | ||
| T2 (0.62–2.03) | 4,744 | 2002 (42.20 %) | 1.22 (1.13, 1.33) | < 0.001 | 1.30 (1.17, 1.43) | < 0.001 |
| T3 (≥ 2.03) | 4,743 | 2545 (53.66 %) | 1.94 (1.79, 2.10) | < 0.001 | 2.09 (1.88, 2.32) | < 0.001 |
| P for trend | < 0.001 | < 0.001 | ||||
| LDL-C/HDL-C ratio (Per 1 SD increase) | 14,227 | 6320 (44.42 %) | 1.45 (1.38, 1.53) | < 0.001 | 1.40 (1.32, 1.50) | < 0.001 |
| Tertiles of LDL/HDL-C ratio | ||||||
| T1 (< 1.49) | 4,741 | 1817 (38.33 %) | Reference | Reference | ||
| T2 (1.49–2.53) | 4,743 | 2040 (43.01 %) | 1.21 (1.12, 1.32) | < 0.001 | 1.31 (1.19, 1.45) | < 0.001 |
| T3 (≥ 2.53) | 4,743 | 2463 (51.93 %) | 1.74 (1.60, 1.89) | < 0.001 | 1.65 (1.49, 1.82) | < 0.001 |
| P for trend | < 0.001 | < 0.001 | ||||
| non-HDL-C (Per 1 mmol/L increase) | 14,227 | 6320 (44.42 %) | 1.19 (1.15, 1.23) | < 0.001 | 1.33 (1.28, 1.39) | < 0.001 |
| Tertiles of non-HDL-C | ||||||
| T1 (< 2.81) | 4,742 | 1933 (40.76 %) | Reference | Reference | ||
| T2 (2.81–4.36) | 4,732 | 2020 (42.69 %) | 1.08 (1.00, 1.17) | 0.0575 | 1.29 (1.17, 1.42) | < 0.001 |
| T3 (≥ 4.36) | 4,753 | 2367 (49.80 %) | 1.44 (1.33, 1.56) | < 0.001 | 1.89 (1.71, 2.09) | < 0.001 |
| P for trend | < 0.001 | < 0.001 | ||||
Abbreviations: OR, odds ratio; CI, confidence interval; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; non-HDL-C, non-high-density lipoprotein cholesterol
Adjusted model: adjusted for age, sex, BMI, SBP, DBP, current smoking, alcohol use, eGFR, Hcy, diabetes mellitus, antihypertensive drugs, and lipid-lowering drugs