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. 2021 Mar 1;18(4):1558–1572. doi: 10.1021/acs.molpharmaceut.0c00968

Table 2. Main Parameters Monitored in Animals during CPT-ALA Toxicity Studya.

parameter control CPT-ALA (0.8 mg/kg)
weight loss (%) 0 5
pain – +
physical alterations – –
behavior disorders + +
a

According to Morton and Griffiths test score: +++ ≡ 3; ++ ≡ 2; + ≡ 1; – ≡ 0.