Table 3.
Follow-up
| ART-Def, Median (IQR) [N] or N (%) | ART-40 W, Median (IQR) [N] or N (%) | ART-96 W, Median (IQR) [N] or N (%) | Total, Median (IQR) [N] or N (%) | |
|---|---|---|---|---|
| Duration of ART (weeks)a,b | ||||
| By week 96 | 84 (72, 84) [44] | – | 96 (96, 96) [73] | 96 (84, 96) [117] |
| By week 248 | 228 (211, 240) [70] | 220 (196, 235) [56] | 216 (168, 247) [43] | 220 (200, 240) [169] |
| Duration of viral suppression (weeks)c | ||||
| By week 248 | 200 (163, 214) [70] | 163 (110, 192) [56] | 164 (108, 200) [43] | 179 (132, 204) [169] |
| Anti-gp120 IgG at week 84 | 5208 (812; 24,751) [60] | – | 218 (133,662) [87] | 420 (169; 13,129) [147] |
| HIV-1 serology at week 84 | ||||
| Negative | 8 (10.1%) | 0 (0%) | 41 (43.6%) | 49 (21.4%) |
| Positive | 52 (65.8%) | 0 (0%) | 44 (46.8%) | 96 (41.9%) |
| Not determined | 19 (24.1%) | 56 (100%) | 9 (9.6%) | 84 (36.7%) |
| CD4% | ||||
| At week 96 | 35 (31, 40) [44] | 31 (29, 34) [2] | 37 (31, 42) [72] | 37 (31, 41) [118] |
| At week 248 | 36 (33, 40) [70] | 34 (29, 39) [54] | 32 (27, 36) [43] | 35 (30, 39) [167] |
| CD4 count (cells/μl) | ||||
| At week 96 | 1650 (1244, 2227) [44] | 1696 (1595, 1797) [2] | 1647 (1131, 2043) [72] | 1650 (1190, 2063) [118] |
| At week 248 | 1175 (885, 1562) [70] | 1110 (866, 1349) [54] | 1039 (755, 1374) [43] | 1115 (866, 1428) [167] |
| HIV-1 DNA (copies/106 PBMC) | ||||
| At week 40 | – | – | 317 (44, 884) [8] | 317 (44, 884) [8] |
| At week 96 | 2415 (499, 7450) [44] | – | 325 (53, 3670) [73] | 681 (106, 5580) [117] |
| At week 156 | 2290 (513; 13,700) [13] | – | – | 2290 (513; 13,700) [13] |
| At week 204 | 625 (175, 2140) [13] | – | – | 625 (175, 2140) [13] |
| At week 248 | 1165 (167; 10,900) [70] | 4165 (294; 26,150) [56] | 915 (172; 15,400) [43] | 1220 (184; 17,300) [169] |
| At week 252 | 58 (18, 129) [10] | – | – | 58 (18, 129) [10] |
aDuration of ART by w96 was determined by calculating time from ART start to w96 HIV DNA measurement i.e., duration of ART by w96 (Arm 1/3) = [w96 HIV DNA date − ART start date] days
bDuration of ART by w248 was determined as follows:
•→Arm 1: calculating time from ART start to w248 HIV DNA measurement i.e., duration of ART by w248 (Arm 1) = [w248 HIV DNA date − ART start date] days.
•→Arms 2 and 3: summing the time from ART start to ART interruption and time from ART restart to w248 HIV DNA measurement, i.e., duration of ART w248 (Arm 2/3) = [ART interruption date − ART start date] + [w248 HIV DNA date − ART restart date] days.
cDuration of VL suppression by w248 was calculated by summing all the periods of time VL < 400 copies/ml. Single isolated VL spikes (i.e., VL ≥ 400 copies/ml) preceded and followed by VL < 400 copies/ml were allowed and counted as VL suppressed