Skip to main content
. 2021 Apr 2;11(8):4660–4669. doi: 10.1021/acscatal.1c00210

Scheme 5. One-Pot Two-Step Stereoselective Synthesis of γ-Hydroxy-α-amino Acids 6, Using Benzylamine (7) as an Amine Donor for the Enzymatic Transamination Reaction and BAL to Transform the Benzaldehyde Formed (8) into Benzoin (9).

Scheme 5

Dotted lines indicate a transamination reaction of the aldehydes 1 and pyruvate 2, favoring the retroaldolysis of 3 catalyzed by the HBPA present in the system.