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. 2021 Apr 2;11(8):4660–4669. doi: 10.1021/acscatal.1c00210

Scheme 6. One-Pot Two-Step Stereoselective Synthesis of γ-Hydroxy-α-amino Acids 6 using l-Glu (10) as an Amine Donor.

Scheme 6

The 2-oxoglutarate (11) formed was transaminated to l-Glu (10) by AspAT using l-Asp (12) as an amine donor. The oxaloacetate (13) decomposes into CO2 and pyruvate, shifting the equilibrium of the transamination to γ-hydroxy-α-amino acids 6.