Scheme 2. Synthesis of Compounds 9–55.
Reagents and conditions: (i) amine, 2-propanol, 110–140 °C, 2–16 h; (ii) sodium hydride, haloalkane, DMF, rt, 5 h; (iii) secondary amine, 2-propanol, 140 °C, 16–96 h or microwave 25 min.
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